People with diabetes, particularly type 2 diabetes, are at increased risk of developing Alzheimer’s disease, the most common form dementia.  Photo Credit: istockphoto
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How Diabetes Increases Risk Of Alzheimer’s Disease

People with diabetes are at an increased risk of developing dementia compared to those without diabetes.

Renu Baliyan

Brain depends on a steady supply of glucose for energy. However, people with diabetes, blood sugar levels stay constantly elevated due to insulin resistance or inadequate insulin production. With time, increased blood sugar may damage the blood vessels throughout the body, including those in brain. When blood vessels in brain get damaged, oxygen and nutrient supply become less efficient. It may lead to cognitive fall and increased risk of Alzheimer’s disease.  

Diabetes can impact blood sugar levels, kidneys, eye sight, and heart health. According to a study, people with diabetes, particularly type 2 diabetes, are at increased risk of developing Alzheimer’s disease, the most common form dementia. It is imperative to comprehend the link between diabetes and Alzheimer’s as it will help individuals take necessary steps to protect their metabolic and cognitive health.  

According to a report featured in Alzheimer’s Society, “People with diabetes are at an increased risk of developing dementia compared to those without diabetes. This was from a review that brought together the findings from 14 studies.”

Studies also indicate that the dementia risk surges with longer duration of diabetes. It has been suggested that diabetes beginning at 70-years of age may not affect dementia risk. Despite these studies, the World Health Organisation (WHO) revealed that diabetes later in life may still cause negative impact on brain health and raise the risk of dementia. People with diabetes will more likely suffer from high blood pressure, high cholesterol, and obesity. Some changes that take place in Alzheimer’s disease bear similarity with those in diabetes.  

Blood Sugar & Brain Connection

Brain depends on a steady supply of glucose for energy. However, people with diabetes, blood sugar levels stay constantly elevated due to insulin resistance or inadequate insulin production. With time, increased blood sugar may damage the blood vessels throughout the body, including those in brain. When blood vessels in brain get damaged, oxygen and nutrient supply become less efficient. It may lead to cognitive fall and increase risk of Alzheimer’s disease.  

Insulin Resistance & Brain

Insulin plays vital role in human body. It is crucial for regulating blood sugar and influence brain functioning. It aids brain cells to communicate and support memory formation. In the case of type 2 diabetes, body may become resistant to insulin. Latest reports indicate that insulin resistance may also take place in brain and impact brain cell functioning too. Some scientists have also started referring to Alzheimer’s disease as type 3 diabetes due to powerful link between insulin resistance and cognitive decline. When brain cells fail to respond effectively to insulin, it can cause memory issues and other symptoms linked to Alzheimer’s.  

Inflammation & Oxidative Stress

Chronic inflammation is yet another shared factor between diabetes and Alzheimer’s disease. Elevated blood sugar can cause inflammation and oxidative stress that can hamper cells and tissues.  Prolonged inflammation in the brain can cause formation of abnormal proteins like beta-amyloid plaques and tau tangles- signs of Alzheimer’s disease. These changes interfere with communication between brain cells and finally lead to their death.  

Vascular Damage & Cognitive Decline

Diabetes enhances risk of cardiovascular disease and stroke. Decreased blood flow to brain can cause vascular dementia and it can worsen symptoms of Alzheimer’s disease. Healthy blood vessels are vital for maintaining cognitive function and diabetes-linked vascular damage can speed up memory loss.  

Lifestyle Factors

Several risk factors for type 2 diabetes that may include obesity, unhealthy diet, reduced physical activities, and high blood pressure can lead to cognitive decline. The overlap can subsequently boost the link between metabolic health and brain health.  

However, individuals can heave a sigh of relief as managing diabetes can bring down the risk of developing Alzheimer’s disease. Regulating blood sugar levels, maintaining healthy diet and weight, and remaining physically active will benefit the body as well as the brain.  

Tips To Protect Brain Health

If you have diabetes, the following steps given below will make a huge difference:

  • Constantly monitor and regulate blood sugar levels.

  • Indulge in regular physical workouts.

  • Eat nutrition rich and balanced diet with whole foods.  

  • Manage blood pressure and cholesterol

  • Never miss on sound sleep

  • Try to remain mentally and socially active  

The link between diabetes and Alzheimer’s disease reflects the significance of whole-body health. While diabetes can surge the risk of cognitive decline, early intervention and healthy lifestyle can significantly protect brain functioning. Managing blood sugar is not just about preventing complication, it will also play key role in protecting long-term memory and cognitive well-being.   

Disclaimer: This content is for general informational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider with any questions about your health or treatment options.

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